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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12767636 B1

PDFFull Text
Date of Patent:
Oct. 20, 2026

Filed:

Apr. 22, 2021

Pharmacological chaperone compounds of human acid α-glucosidase and the therapeutic use thereof

Applicants:

Université Grenoble Alpes, Saint Martin d'Hères, FR;

Centre National DE LA Recherche Scientifique, Paris, FR;

Inventors:

Sandrine Py, Saint Martin d'Uriage, FR;

Alice Kanazawa, Bernin, FR;

Anaïs Vieira Da Cruz, Moirans, FR;

Salia Tangara, Lille, FR;

Assignees:

UNIVERSITÉ GRENOBLE ALPES, Saint Martin d'Héres, FR;

CENTRE NATIONAL DE LA RECHERCHE SCENITFIQUE, Paris, FR;

Attorney:

NIXON & VANDERHYE

Primary Examiner:

Kamal A Saeed

Assistant Examiner:

Quincy undefined Mckoy

Int. Cl.
CPC ...
C07D 211/46 (2006.01); C07D 401/04 (2006.01); C07D 401/12 (2006.01); C07D 405/12 (2006.01); C07D 455/02 (2006.01); C07D 471/04 (2006.01);
U.S. Cl.
CPC ...
C07D 211/46 (2013.01); C07D 401/04 (2013.01); C07D 401/12 (2013.01); C07D 405/12 (2013.01); C07D 455/02 (2013.01); C07D 471/04 (2013.01);
Abstract

The invention concerns particular compounds of the iminosugars class, with a piperidine ring, having a D-gluco configuration and comprising a quaternary centre in the a position of the nitrogen of the piperidine ring. These compounds have the ability to stabilize human acid α-glucosidase while being selective with respect to other glycosidases. They are particularly advantageous for use as chaperone molecules of this enzyme for the treatment of Pompe disease.

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Quick Actions:

Py, Sandrine. (2026). Pharmacological chaperone compounds of human acid α-glucosidase and the therapeutic use thereof (U.S. Patent No. 12767636). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12767636

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