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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12766150 B1

PDFFull Text
Date of Patent:
Oct. 20, 2026

Filed:

Dec. 01, 2021

Substituted thiadiazolyl derivatives as dna polymerase theta inhibitors

Applicants:

Ideaya Biosciences, Inc., South San Francisco, CA (US);

Glaxosmithkline Intellectual Property (No. 4) Limited, Stevenage, GB;

Inventors:

Paul A. Barsanti, South San Francisco, CA (US);

Hilary Plake Beck, South San Francisco, CA (US);

Melissa Fleury, South San Francisco, CA (US);

Brian Thomas Jones, South San Francisco, CA (US);

Ethan Denardo Mcspadden, South San Francisco, CA (US);

Zhonghua Pei, South San Francisco, CA (US);

Chenbo Wang, South San Francisco, CA (US);

Firoz Ali Jaipuri, South San Francisco, CA (US);

Daniel Lee Severance, South San Francisco, CA (US);

Kevin J. Duffy, Collegeville, PA (US);

Brian Lawhorn, Collegeville, PA (US);

Assignees:

IDEAYA Biosciences, Inc., South San Francisco, CA (US);

GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.4) LIMITED, Stevenage, GB;

Attorney:

Bryan Cave Leighton Paisner LLP

Primary Examiner:

James H Alstrum-Acevedo

Assistant Examiner:

Carolyn L. Ladd

Int. Cl.
CPC ...
A61K 31/5377 (2006.01); A61K 31/433 (2006.01); A61K 31/437 (2006.01); A61K 31/4439 (2006.01); A61K 31/444 (2006.01); A61K 31/4709 (2006.01); A61K 31/497 (2006.01); A61K 31/501 (2006.01); A61K 31/506 (2006.01); C07D 417/12 (2006.01); C07D 417/14 (2006.01); C07D 471/04 (2006.01); C07D 471/08 (2006.01); C07D 491/052 (2006.01); C07D 491/056 (2006.01); C07D 493/10 (2006.01);
U.S. Cl.
CPC ...
A61K 31/5377 (2013.01); A61K 31/433 (2013.01); A61K 31/437 (2013.01); A61K 31/4439 (2013.01); A61K 31/444 (2013.01); A61K 31/4709 (2013.01); A61K 31/497 (2013.01); A61K 31/501 (2013.01); A61K 31/506 (2013.01); C07D 417/12 (2013.01); C07D 417/14 (2013.01); C07D 471/04 (2013.01); C07D 471/08 (2013.01); C07D 491/052 (2013.01); C07D 491/056 (2013.01); C07D 493/10 (2013.01);
Abstract

Disclosed herein are certain thiadiazolyl derivatives of Formula (I), (II), (III), or (IV): that inhibit DNA Polymerase Theta (Polθ) activity, in particular inhibit Polθ activity by inhibiting ATP dependent helicase domain activity of Polθ. Also, disclosed are pharmaceutical compositions comprising such compounds and methods of treating and/or preventing diseases treatable by inhibition of Polθ such as cancer, including homologous recombination (HR) deficient cancers.

Find Patent Forward Citations

Barsanti, Paul. (2026). Substituted thiadiazolyl derivatives as dna polymerase theta inhibitors (U.S. Patent No. 12766150). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12766150

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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