The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 13, 2026
Filed:
Jan. 19, 2022
The Regents of the University of Michigan, Ann Arbor, MI (US);
The Board of Trustees of the University of Illinois, Urbana, IL (US);
The Penn State Research Foundation, University Park, PA (US);
George Garcia, Ann Arbor, MI (US);
Hollis Showalter, Ann Arbor, MI (US);
Walajapet Rajeswaran, Ann Arbor, MI (US);
Pil Lee, Ann Arbor, MI (US);
Scott Franzblau, Urbana, IL (US);
Katsuhiko Murakami, University Park, PA (US);
THE REGENTS OF THE UNIVERSITY OF MICHIGAN, Ann Arbor, MI (US);
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS, Urbana, IL (US);
THE PENN STATE RESEARCH FOUNDATION, University Park, PA (US);
Abstract
Provided herein are compounds that are potent inhibitors of the(MTB) RNA polymerase (RNAP), which exhibit significantly reduced activation of the human pregnane X receptor (hPXR), resulting in dramatically reduced C induction of hepatic cytochromes P450 2C9 and 3A4 (CYP2C9, CYP3A4), as well as a number of Phase II metabolism enzymes. Also provided herein are pharmaceutical compositions comprising the compounds, and methods of treating tuberculosis using the compounds.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile