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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12760026 B1

PDFFull Text
Date of Patent:
Oct. 13, 2026

Filed:

Mar. 14, 2022

Heteroaroyl amides as lrrk2 inhibitors, pharmaceutical compositions, and uses thereof

Applicant:

Merck Sharp & Dohme Llc, Rahway, NJ (US);

Inventors:

Kaleen Konrad Childers, Medfield, MA (US);

J. Michael Ellis, Milton, MA (US);

Peter J. Fuller, Ashland, MA (US);

Hakan Gunaydin, Belmont, MA (US);

Jack D. Scott, Scotch Plains, NJ (US);

Haiqun Tang, Belle Mead, NJ (US);

Charles S. Yeung, Dedham, MA (US);

Assignee:

Merck Sharp & Dohme LLC, Rahway, NJ (US);

Attorneys:

Sylvia A. Ayler

Catherine Fitch

Primary Examiner:

John S Kenyon

Int. Cl.
CPC ...
C07D 487/04 (2006.01); A61K 31/4155 (2006.01); A61K 31/422 (2006.01); A61K 31/427 (2006.01); A61K 31/437 (2006.01); A61K 31/4439 (2006.01); A61K 31/496 (2006.01); A61K 31/506 (2006.01); A61K 31/5365 (2006.01); A61K 31/5377 (2006.01); A61K 31/55 (2006.01); C07D 401/12 (2006.01); C07D 401/14 (2006.01); C07D 403/12 (2006.01); C07D 403/14 (2006.01); C07D 413/12 (2006.01); C07D 413/14 (2006.01); C07D 417/12 (2006.01); C07D 417/14 (2006.01); C07D 471/04 (2006.01); C07D 498/04 (2006.01);
U.S. Cl.
CPC ...
C07D 487/04 (2013.01); A61K 31/4155 (2013.01); A61K 31/422 (2013.01); A61K 31/427 (2013.01); A61K 31/437 (2013.01); A61K 31/4439 (2013.01); A61K 31/496 (2013.01); A61K 31/506 (2013.01); A61K 31/5365 (2013.01); A61K 31/5377 (2013.01); A61K 31/55 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 403/12 (2013.01); C07D 403/14 (2013.01); C07D 413/12 (2013.01); C07D 413/14 (2013.01); C07D 417/12 (2013.01); C07D 417/14 (2013.01); C07D 471/04 (2013.01); C07D 498/04 (2013.01);
Abstract

The present invention is directed to certain (hetero)aroyl 4-aminopyrazole derivatives of Formula (I) and pharmaceutically acceptable salts thereof, wherein A, R, R, and Rare as defined herein, which are potent inhibitors of LRRK2 kinase and may be useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease and other diseases and disorders described herein. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which LRRK-2 kinase is involved.

Find Patent Forward Citations

Childers, Kaleen. (2026). Heteroaroyl amides as lrrk2 inhibitors, pharmaceutical compositions, and uses thereof (U.S. Patent No. 12760026). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12760026

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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