Sik inhibitors

Abstract

A compound of formula I having the structure: or a pharmaceutically acceptable salt thereof, wherein Aand Aare independently O or S; X is selected from CH, CD, NR, O, and S, where Ris selected from hydrogen, C-Clinear or branched chain alkyl, halo(C-C)linear or branched chain alkyl, and hydroxyl(C-C)linear or branched chain alkyl; Y and Z are selected from C and N, where when Y is C, then Z is N, and when Y is N, then Z is C; Rand Rare independently selected from hydrogen, deuterium, C-Clinear or branched chain alkyl, etc.; or a C-Calkyl substituted with a C-Ccycloalkyl ring; or taken together to form a C-Ccycloalkyl ring; or where X is CHor CD, then Rand Rare independently selected from hydrogen, deuterium, halogen, hydroxyl, C-Clinear or branched chain alkyl, etc.; Ris selected from hydrogen, deuterium, cyano, halogen, (C-C) alkoxy, etc.; Ris selected from hydrogen, deuterium, halogen, C-Calkoxy, amino, (C-Clinear or branched chain alkyl)amino, etc.; Ris selected from hydrogen, deuterium, halogen, CORwhere Ris selected from H and C-Clinear or branched chain alkyl, etc.; Ris selected from hydrogen, deuterium, and C-Clinear or branched chain alkyl; Ris selected from C-Clinear or branched chain alkyl, and a halo(C-C)linear or branched chain alkyl; and, n and m are independently selected from 0, 1 and 2. The invention also relates to pharmaceutical compositions thereof and therapeutic methods of use therewith.