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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12758557 B1

PDFFull Text
Date of Patent:
Oct. 13, 2026

Filed:

Jan. 14, 2022

Small molecule regulators of alveolar type 2 cell proliferation for the treatment of pulmonary diseases

Applicant:

The Scripps Research Institute, La Jolla, CA (US);

Inventors:

Michael J. Bollong, San Diego, CA (US);

Peter G. Schultz, La Jolla, CA (US);

Sida Shao, San Diego, CA (US);

Arnab Chatterjee, San Diego, CA (US);

Jian Jeffrey Chen, San Diego, CA (US);

Nan Zhang, San Diego, CA (US);

Assignee:

THE SCRIPPS RESEARCH INSTITUTE, La Jolla, CA (US);

Attorney:

Viksnins Harris Padys Malen LLP

Primary Examiner:

Sarah Pihonak

Int. Cl.
CPC ...
A61K 31/522 (2006.01); A61K 31/40 (2006.01); A61K 31/403 (2006.01); A61K 31/4162 (2006.01); A61K 31/495 (2006.01); A61K 31/496 (2006.01); A61K 31/4985 (2006.01); A61K 31/513 (2006.01); A61K 31/519 (2006.01); A61K 31/551 (2006.01); A61K 31/69 (2006.01); A61P 11/00 (2006.01);
U.S. Cl.
CPC ...
A61K 31/522 (2013.01); A61K 31/40 (2013.01); A61K 31/403 (2013.01); A61K 31/4162 (2013.01); A61K 31/495 (2013.01); A61K 31/496 (2013.01); A61K 31/4985 (2013.01); A61K 31/513 (2013.01); A61K 31/519 (2013.01); A61K 31/551 (2013.01); A61K 31/69 (2013.01); A61P 11/00 (2018.01);
Abstract

The present disclosure relates to compounds. and to their pharmaceutical compositions. that inhibit dipeptidyl peptidase IV (DPP4). Hie compounds selectively promote the proliferation of alveolar type 2 cells (AEC2s) and are useful in therapeutic methods of treating diseases whose etiology, for example, derives from epithelial degeneration and maladaptive remodeling, such as pulmonary' diseases like idiopathic pulmonary fibrosis (IFF), acute respiratory' distress syndrome (ARDS), and infant respiratory' distress syndromes (IRDS).

Find Patent Forward Citations

Bollong, Michael. (2026). Small molecule regulators of alveolar type 2 cell proliferation for the treatment of pulmonary diseases (U.S. Patent No. 12758557). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12758557

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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