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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12758525 B1

PDFFull Text
Date of Patent:
Oct. 13, 2026

Filed:

Apr. 01, 2022

Combination treatment methods of multiple sclerosis

Applicant:

Biogen MA Inc., Cambridge, MA (US);

Inventors:

Michael Joseph Palte, Melrose, MA (US);

Brian T. Hopkins, Newton, MA (US);

Matthew P. Scaramozza, West Roxbury, MA (US);

Michael Christian Mingueneau, Somerville, MA (US);

Alex Pellerin, Dorchester, MA (US);

Chelsea R. Parker Harp, Boston, MA (US);

Catherine Barbey, Lausanne, CH;

Assignee:

BIOGEN MA INC., Cambridge, MA (US);

Attorneys:

McCarter & English, LLP

Xin Zhang

Primary Examiner:

Kevin E Weddington

Int. Cl.
CPC ...
A61K 31/4015 (2006.01); A61K 31/225 (2006.01); A61K 31/4545 (2006.01); A61K 31/4985 (2006.01); A61K 31/506 (2006.01); A61P 25/28 (2006.01); A61P 37/00 (2006.01);
U.S. Cl.
CPC ...
A61K 31/4015 (2013.01); A61K 31/225 (2013.01); A61K 31/4545 (2013.01); A61K 31/4985 (2013.01); A61K 31/506 (2013.01); A61P 25/28 (2018.01); A61P 37/00 (2018.01);
Abstract

The present disclosure provides combination therapies for treating an autoimmune disease in a subject in need thereof. The methods comprise administering to the subject an effective amount of a BTK inhibitor in combination with an effective amount of a fumaric acid ester (FAE). The autoimmune disease can be treated include, for example, multiple sclerosis (MS), lupus, rheumatoid arthritis (RA), Pemphigus Vugaris (PV), neuromyelitis optica (NMO), myasthenia gravis (MG), chronic inflammatory demyelinating polyneuropathy (CIDP), anti-NMDA receptor encephalitis, or Sjogren's disease.

Find Patent Forward Citations

Palte, Michael. (2026). Combination treatment methods of multiple sclerosis (U.S. Patent No. 12758525). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12758525

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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