The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 06, 2026
Filed:
Oct. 24, 2022
Applicant:
Merck Sharp & Dohme Llc, Rahway, NJ (US);
Inventors:
Abdelghani Abe Achab, Melrose, MA (US);
Jenny Lorena Rico Duque, Canton, MA (US);
Xavier Fradera, Boston, MA (US);
Joey L. Methot, Westwood, MA (US);
Phieng Siliphaivanh, Newton, MA (US);
Brandon A Vara, Boston, MA (US);
Hongjun Zhang, Boston, MA (US);
Assignee:
Merck Sharp & Dohme LLC, Rahway, NJ (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 519/00 (2006.01); A61K 31/438 (2006.01); A61K 31/4709 (2006.01); A61K 31/519 (2006.01); C07D 471/20 (2006.01);
U.S. Cl.
CPC ...
C07D 519/00 (2013.01); A61K 31/438 (2013.01); A61K 31/4709 (2013.01); A61K 31/519 (2013.01); C07D 471/20 (2013.01);
Abstract
Described herein are compounds of Formula I; and pharmaceutically acceptable salts thereof, wherein A, X, R, R, m, n, and p are as defined herein. The compounds of Formula I, and pharmaceutically acceptable salts thereof, act as RIPK1 inhibitors and can be useful in preventing, treating or acting as a remedial agent for RIPK1-related diseases.