The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 06, 2026

Filed:

Mar. 21, 2022
Applicant:

Bracco Imaging Spa, Milan, IT;

Inventors:

Luciano Lattuada, Cassina de'Pecchi, IT;

Giovanni Battista Giovenzana, Novara, IT;

Camilla Cavallotti, Novara, IT;

Ivan Menegotto, Borgomanero, IT;

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07C 213/02 (2006.01); C07C 231/02 (2006.01); C07C 231/12 (2006.01); C07D 263/24 (2006.01);
U.S. Cl.
CPC ...
C07C 213/02 (2013.01); C07C 231/02 (2013.01); C07C 231/12 (2013.01); C07D 263/24 (2013.01);
Abstract

The present invention is related to the synthesis of 4-hydroxymethyl-2-oxazolidinone (serinol carbamate, SC), which can be subsequently hydrolyzed to 2-amino-1,3-propanediol (serinol), by reacting glycerol and urea: (I) In general, glycerol is heated with urea and a catalyst, with or without a solvent, to give mainly 4-hydroxymethyl-2-oxazolidinone (serinol carbamate, SC), which is hydrolyzed in the next step to 2-amino-1,3-propanediol (serinol). Alternatively, glycerol 1,2-carbonate can be used instead of glycerol. Serinol obtained by the process of the invention may be used in the synthesis of Iopamidol.


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