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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12751999 B1

PDFFull Text
Date of Patent:
Oct. 06, 2026

Filed:

Jun. 11, 2021

Lipid nanoparticles comprising sterols and mrna

Applicants:

Etherna Immunotherapies NV, Niel, BE;

Vrije Universiteit Brussel, Brussels, BE;

Inventors:

Sanne Bevers, Niel, BE;

Stefaan De Koker, Niel, BE;

Raymond Michel Schiffelers, Yalelaan, NL;

Sander Alexander Antonius Kooijmans, Yalelaan, NL;

Assignees:

eTheRNA Immunitherapies NV, Niel, BE;

Vrije Universiteit Brussel, Brussels, BE;

Attorney:

DINSMORE & SHOHL LLP

Primary Examiner:

Elly-Gerald Stoica

Int. Cl.
CPC ...
A61K 39/00 (2006.01); A61K 9/51 (2006.01); A61K 47/24 (2006.01); A61K 47/28 (2006.01); A61P 35/00 (2006.01); A61P 37/04 (2006.01);
U.S. Cl.
CPC ...
A61K 39/001117 (2018.08); A61K 9/5123 (2013.01); A61K 9/5146 (2013.01); A61K 39/0011 (2013.01); A61K 39/001102 (2018.08); A61K 47/24 (2013.01); A61K 47/28 (2013.01); A61P 35/00 (2018.01); A61P 37/04 (2018.01); A61K 2039/53 (2013.01); A61K 2039/575 (2013.01);
Abstract

The present invention relates to the field of lipid nanoparticles (LNP); more specifically comprising an ionizable lipid, a phospholipid, a sterol, a PEG lipid and one or more nucleic acids. The LNP's of the present invention are characterized in comprising less than about 1 mol % of a C14-PEG2000 lipid; as well as particular percentages of the other lipids. The present invention provides use of the LNP's for immunogenic delivery of nucleic acid molecules, specifically mRNA; thereby making them highly suitable for use in vaccines, such as for the treatment of cancer or infectious diseases. Finally, methods are provided for preparing such LNP's.

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Bevers, Sanne. (2026). Lipid nanoparticles comprising sterols and mrna (U.S. Patent No. 12751999). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12751999

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