The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 29, 2026

Filed:

Mar. 27, 2020
Applicant:

University of Virginia Patent Foundation, Charlottesville, VA (US);

Inventors:

Paul Andrew Yates, Charlottesville, VA (US);

Elias Reichel, Weston, MA (US);

Ashton Leone, Charlottesville, VA (US);

Assignees:

University of Virginia Patent Foundation, Charlottesville, VA (US);

Tufts Medical Center, Inc., Boston, MA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/65 (2006.01); A61P 27/02 (2006.01);
U.S. Cl.
CPC ...
A61K 31/65 (2013.01); A61P 27/02 (2018.01);
Abstract

Provided are chemically modified tetracycline (CMT) derivatives for the treatment of non-exudative macular degeneration. The CMT derivatives lack antimicrobial activity, include a phenol ring, and a chemical structure sufficient to chelate Zn2+. Methods of inhibiting and/or minimizing inflammation in a subject, including administering to the subject a dose of a CMT derivative, are also provided. Methods of treating non-exudative age-related macular degeneration (AMD) are provided.


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