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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12746202 B1

PDFFull Text
Date of Patent:
Sep. 29, 2026

Filed:

Mar. 24, 2023

Cationic lipid having disulfide bond, lipid membrane structure including same, nucleic acid introduction agent and pharmaceutical composition containing any one of same, method for introducing nucleic acid into cell or target cell, and method for producing cellular pharmaceutical

Applicants:

Nof Corporation, Tokyo, JP;

National University Corporation Chiba University, Chiba, JP;

Inventors:

Masamichi Tamada, Kawasaki, JP;

Tokihiro Tanaka, Kawasaki, JP;

Shinya Tamagawa, Kawasaki, JP;

Kota Tange, Kawasaki, JP;

Yuta Nakai, Kawasaki, JP;

Kasumi Ito, Kawasaki, JP;

Hidetaka Akita, Chiba, JP;

Hiroki Tanaka, Chiba, JP;

Yu Sakurai, Chiba, JP;

Yuka Sato, Chiba Chiba, JP;

Assignees:

NOF Corporation, Tokyo, JP;

National University Corporation Chiba University, Chiba, JP;

Attorney:

Leydig, Voit & Mayer, Ltd.

Primary Examiner:

Brian Gulledge

Int. Cl.
CPC ...
A61K 9/127 (2025.01); A61K 9/1272 (2025.01); A61K 9/51 (2006.01); A61K 48/00 (2006.01); C07C 323/12 (2006.01); C07C 323/25 (2006.01); C07C 323/41 (2006.01); C07D 211/14 (2006.01); C12N 15/88 (2006.01);
U.S. Cl.
CPC ...
A61K 9/1272 (2013.01); A61K 9/5123 (2013.01); A61K 48/0033 (2013.01); C07C 323/12 (2013.01); C07C 323/25 (2013.01); C07C 323/41 (2013.01); C07D 211/14 (2013.01); C12N 15/88 (2013.01);
Abstract

The present invention provides a cationic lipid that can be used as a nucleic acid delivery carrier with good intracellular dynamics, a lipid membrane structure containing the same, a nucleic acid-introducing agent and a pharmaceutical composition containing any of them, a method for introducing nucleic acid into cells or target cells, and a method for producing a cell medicine. A cationic lipid represented by the formula (1) (definitions of symbols in the formula are as described in the specification), a lipid membrane structure using the aforementioned cationic lipid, a nucleic acid-introducing agent and a pharmaceutical composition using the aforementioned cationic lipid or the aforementioned lipid membrane structure, a method for introducing nucleic acid into cells or target cells by using the aforementioned nucleic acid-introducing agent, and a method for producing a cell medicine by using the aforementioned nucleic acid-introducing agent.

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