Hydrogel patch including additive solution adjustable for its syneresis pattern and method of manufacturing the composition

Abstract

Provided are a method for preparing a hydrogel patch containing a filling solution for controlling a syneresis pattern. The method includes: separately stirring a phase A consisting of a crosslinking agent and purified water, a phase B consisting of an organic polymer and a polyhydric alcohol, and a phase C consisting of a pH adjusting agent and purified water, and then sequentially adding the phase B and the phase C to the phase A, thereby preparing a hydrogel; separately stirring a phase D consisting of a humectant and purified water, a phase E consisting of a thickener and a polyhydric alcohol, and a phase F consisting of a pH adjusting agent and purified water, and then sequentially adding the phase E and the phase F to the phase D, thereby preparing a filling solution; and filling the hydrogel with the filling solution.