The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 22, 2026
Filed:
Feb. 10, 2022
Applicant:
Ionis Pharmaceuticals, Inc., Carlsbad, CA (US);
Inventors:
Adam Mullick, Carlsbad, CA (US);
Huynh-Hoa Bui, Carlsbad, CA (US);
Susan M. Freier, Carlsbad, CA (US);
Ting Yuan Yeh, Carlsbad, CA (US);
Dieter Kubli, Carlsbad, CA (US);
Assignee:
IONIS PHARMACEUTICALS INC., Carlsbad, CA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 15/113 (2010.01); A61P 9/10 (2006.01); C07K 14/705 (2006.01); C07K 16/28 (2006.01); C12N 9/22 (2006.01); C12N 15/115 (2010.01);
U.S. Cl.
CPC ...
C12N 15/113 (2013.01); A61P 9/10 (2018.01); C07K 14/70582 (2013.01); C07K 16/2881 (2013.01); C12N 9/22 (2013.01); C12N 15/115 (2013.01); C12N 2310/14 (2013.01); C12N 2310/314 (2013.01); C12N 2310/315 (2013.01); C12N 2310/321 (2013.01); C12N 2310/322 (2013.01); C12N 2310/3341 (2013.01); C12N 2310/3525 (2013.01); C12Y 301/26004 (2013.01);
Abstract
Provided are oligomeric agents, oligomeric compounds, methods, and pharmaceutical compositions for reducing the amount or activity of PLN RNA in a cell or animal, and in certain instances reducing the amount of PLN protein in a cell or animal. Such oligomeric agents, oligomeric compounds, methods, and pharmaceutical compositions are useful to treat cardiomyopathy, heart failure, or arrhythmia.