The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 22, 2026
Filed:
Dec. 09, 2021
Applicant:
The Scripps Research Institute, La Jolla, CA (US);
Inventors:
Assignee:
THE SCRIPPS RESEARCH INSTITUTE, La Jolla, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 213/803 (2006.01); C07C 51/373 (2006.01); C07C 227/10 (2006.01); C07C 231/12 (2006.01); C07C 303/40 (2006.01); C07D 209/08 (2006.01); C07D 209/26 (2006.01); C07D 209/86 (2006.01); C07D 213/55 (2006.01); C07D 213/61 (2006.01); C07D 213/643 (2006.01); C07D 213/69 (2006.01); C07D 213/74 (2006.01); C07D 215/48 (2006.01); C07D 215/50 (2006.01); C07D 235/20 (2006.01); C07D 241/42 (2006.01); C07D 271/06 (2006.01); C07D 277/64 (2006.01); C07D 295/155 (2006.01); C07D 307/79 (2006.01); C07D 307/91 (2006.01); C07D 319/18 (2006.01); C07D 333/54 (2006.01); C07D 333/76 (2006.01); C07F 15/00 (2006.01); C07K 5/065 (2006.01);
U.S. Cl.
CPC ...
C07D 213/803 (2013.01); C07C 51/373 (2013.01); C07C 227/10 (2013.01); C07C 231/12 (2013.01); C07C 303/40 (2013.01); C07D 209/08 (2013.01); C07D 209/26 (2013.01); C07D 209/86 (2013.01); C07D 213/55 (2013.01); C07D 213/61 (2013.01); C07D 213/643 (2013.01); C07D 213/69 (2013.01); C07D 213/74 (2013.01); C07D 215/48 (2013.01); C07D 215/50 (2013.01); C07D 235/20 (2013.01); C07D 241/42 (2013.01); C07D 271/06 (2013.01); C07D 277/64 (2013.01); C07D 295/155 (2013.01); C07D 307/79 (2013.01); C07D 307/91 (2013.01); C07D 319/18 (2013.01); C07D 333/54 (2013.01); C07D 333/76 (2013.01); C07F 15/0066 (2013.01); C07K 5/06078 (2013.01);
Abstract
Disclosed herein is a process for making a compound of formula (2) by (hetero)aromatic C—H hydroxylation of a compound of formula (1): catalyzed by palladium(II) and a bidentate ligand in the presence of O. The process is useful for instance, in the late-stage modification of medicinally important heterocycles.