The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 22, 2026

Filed:

Jan. 06, 2020
Applicants:

University of Vermont and State Agricultural College, Burlington, VT (US);

RS Oncology, Llc, Cambridge, MA (US);

Wake Forest University Health Sciences, Winston-Salem, NC (US);

Inventors:

Brian Cunniff, Burlington, VT (US);

Gregory Frykman, Cambridge, MA (US);

Kimberly Johnson Nelson, Winston-Salem, NC (US);

Assignees:

University of Vermont and State Agricultural College, Burlington, VT (US);

RS Oncology, LLC, Cambridge, MA (US);

Wake Forest University Health Sciences, Winston-Salem, NC (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/12 (2006.01); A61K 31/355 (2006.01); A61P 35/00 (2006.01);
U.S. Cl.
CPC ...
A61K 38/12 (2013.01); A61K 31/355 (2013.01); A61P 35/00 (2018.01);
Abstract

The invention relates, in part, to compounds, compositions, and methods useful to treat cancer in cells and subjects. The invention relates, in part, to compounds, compositions, and methods useful to treat cancer in cells and subjects. According to one aspect of the invention, methods for reducing cell viability in a population cells comprising cancer cells are provided, the methods including: contacting a population of cells that include cancer cells with Thiostrepton (TS) and Vitamin E-TPGS, under conditions and for a period of time sufficient for a statistically significant reduction in viability in a plurality of the cancer cells.


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