The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 15, 2026

Filed:

Oct. 02, 2019
Applicant:

Agilent Technologies, Inc., Santa Clara, CA (US);

Inventors:

Ashutosh, San Jose, CA (US);

Devendra Joshi, Santa Clara, CA (US);

Christian A. Le Cocq, Menlo Park, CA (US);

Assignee:

AGILENT TECHNOLOGIES, INC., Santa Clara, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G16B 30/20 (2019.01); C12Q 1/6869 (2018.01); C12Q 1/6886 (2018.01); G16B 30/00 (2019.01); G16B 30/10 (2019.01);
U.S. Cl.
CPC ...
G16B 30/20 (2019.02); C12Q 1/6869 (2013.01); C12Q 1/6886 (2013.01); G16B 30/00 (2019.02); G16B 30/10 (2019.02); C12Q 2600/156 (2013.01);
Abstract

Provided herein is a method for identifying a sequence variant in an enriched sample. In certain embodiments, this method may comprise: (a) obtaining: (i) a plurality of sequence reads from a sample that has been enriched for a genomic region and (ii) a reference sequence for the genomic region; (b) assembling the sequence reads to obtain a plurality of discrete sequence assemblies that correspond to potential variants; (c) determining which of the potential variants are true and which are artifacts by examining the sequence reads that make up each of the discrete sequence assemblies; (d) optionally determining whether each of the true potential variants contains a mutation that is known to be associated with the reference sequence; and (e) outputting a report indicating whether the sample comprises a sequence variant.


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