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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12735432 B1

PDFFull Text
Date of Patent:
Sep. 15, 2026

Filed:

Apr. 19, 2022

Parp inhibitor containing piperazine structure. preparation method therefor and pharmaceutical use thereof

Applicant:

Wigen Biomedicine Technology (Shanghai) Co., Ltd., Shanghai, CN;

Inventors:

Yuli Xie, Shanghai, CN;

Yongcong Lv, Shanghai, CN;

Lihui Qian, Shanghai, CN;

Houxing Fan, Shanghai, CN;

Assignee:

WIGEN BIOMEDICINE TECHNOLOGY (SHANGHAI) CO., LTD., Shanghai, CN;

Attorney:

SZDC Law PC

Primary Examiner:

Matthew P Coughlin

Assistant Examiner:

Ashli A Chicks

Int. Cl.
CPC ...
C07D 498/04 (2006.01); A61K 31/496 (2006.01); A61K 31/497 (2006.01); A61K 31/498 (2006.01); A61K 31/4985 (2006.01); A61K 31/501 (2006.01); A61K 31/506 (2006.01); A61K 31/5383 (2006.01); C07D 401/14 (2006.01); C07D 471/04 (2006.01);
U.S. Cl.
CPC ...
C07D 498/04 (2013.01); A61K 31/496 (2013.01); A61K 31/497 (2013.01); A61K 31/498 (2013.01); A61K 31/4985 (2013.01); A61K 31/501 (2013.01); A61K 31/506 (2013.01); A61K 31/5383 (2013.01); C07D 401/14 (2013.01); C07D 471/04 (2013.01);
Abstract

Disclosed in the present invention are a PARP inhibitor containing a piperazine structure, a preparation method therefor and pharmaceutical use thereof. Particularly, the present invention relates to novel compounds of general formulas (1), (2), (3), (4) and (5) and/or a pharmaceutically acceptable salt thereof, a composition comprising the compounds of general formulas (1), (2), (3), (4) and (5) and/or the pharmaceutically acceptable salt thereof, a preparation method therefor and use thereof as a PARP inhibitor in the preparation of anti-tumor drugs.

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