The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 08, 2026

Filed:

Mar. 16, 2021
Applicant:

Flow Pharma, Inc., Redwood City, CA (US);

Inventors:

Reid M. Rubsamen, Alamno, CA (US);

Scott Burkholtz, Redwood City, CA (US);

Charles V. Herst, Oakland, CA (US);

Tom Hodge, Redwood City, CA (US);

Lu Wang, San Jose, CA (US);

Assignee:

Flow Pharma, Inc., Redwood City, CA (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 16/24 (2006.01); A61K 9/00 (2006.01); A61K 39/00 (2006.01); A61K 47/68 (2017.01); C07K 16/28 (2006.01); G01N 33/68 (2006.01); A61K 9/16 (2006.01);
U.S. Cl.
CPC ...
C07K 16/248 (2013.01); A61K 47/6883 (2017.08); C07K 16/2866 (2013.01); G01N 33/6869 (2013.01); G01N 2333/5412 (2013.01);
Abstract

An injectable formulation, comprising: poly(lactic-co-glycolic (PLGA) microsphere encapsulating siltuximab, wherein microspheres are sized to release siltuximab over a period of hours, days and weeks, where the biocompatible polymer releases antibody at an absorption rate which is characterized by an absorption rate constant (Ka (h) in the range of (to)+/−20%, or +/−10%, or +/−5% . . . for use and treating human patients with infections. The invention includes treating patients with viral infections of SARS-Cov-using siltuximab.


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