The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 08, 2026

Filed:

Oct. 19, 2021
Applicant:

Amgen Inc., Thousand Oaks, CA (US);

Inventors:

Brian Alan Lanman, Woodland Hills, CA (US);

Abhisek Banerjee, Bangalore, IN;

Margaret Chu-Moyer, Brookline, MA (US);

Dongcheng Dai, Corvallis, OR (US);

Josephine Eshon, Ithaca, NY (US);

David Huang, Thousand Oaks, CA (US);

Matthew R. Kaller, Ventura, CA (US);

Heejun Lee, Thousand Oaks, CA (US);

Patricia Lopez, Woodland Hills, CA (US);

Vu Van MA, Oak Park, CA (US);

Francesco Manoni, Newbury Park, CA (US);

Jose M Medina, Thousand Oaks, CA (US);

Alexander J. Pickrell, Westlake Village, CA (US);

John C. Stellwagen, Newbury Park, CA (US);

Zhen Sun, Shanghai, CN;

Nuria A. Tamayo, Newbury Park, CA (US);

Wenhan Zhang, Thousand Oaks, CA (US);

Kai Zhu, Westlake Village, CA (US);

Assignee:

AMGEN INC., Thousand Oaks, CA (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 487/10 (2006.01); A61K 45/06 (2006.01); A61P 35/00 (2006.01); C07D 519/00 (2006.01);
U.S. Cl.
CPC ...
C07D 487/10 (2013.01); A61K 45/06 (2013.01); A61P 35/00 (2018.01); C07D 519/00 (2013.01);
Abstract

Provided are compounds of Formula (I) having activity as inhibitors of G12C mutant KRAS protein, pharmaceutical compositions comprising the compounds, and uses and methods of treating certain disorders, such as cancer, including but not limited to lung, pancreatic and colorectal cancers.


Find Patent Forward Citations

Lanman, Brian. (2026). Heterocyclic spiro compounds and methods of use (U.S. Patent No. 12729207). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12729207

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

Loading…