Prodrugs for sustained releasing therapeutic agents and uses thereof

Abstract

The present disclosure relates to prodrugs for sustained releasing therapeutic agents, and methods for using such prodrugs for the treatment of diseases. The present disclosure provides a prodrug compound comprising a parent drug moiety and a tail moiety, wherein the parent drug moiety is derived from a parent drug comprising a reactive group selected from the group consisting of amine, amino, hydroxyl, carboxylate, ketone, and amide, the tail moiety is covalently linked to the parent drug moiety and has a Formula (I): a pharmaceutical composition comprising the prodrug compound provided herein or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable excipient, and a method of treating diseases in a subject in need thereof.