The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 08, 2026

Filed:

Oct. 21, 2022
Applicant:

Mcmaster University, Hamilton, CA;

Inventors:

Zahra Keshavarz Motamed, Ancaster, CA;

Nikrouz Bahadormanesh, Hamilton, CA;

Assignee:

McMaster University, Hamilton, CA;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61B 8/00 (2006.01); A61B 8/08 (2006.01);
U.S. Cl.
CPC ...
A61B 8/488 (2013.01); A61B 8/0883 (2013.01); A61B 8/0891 (2013.01); A61B 8/5246 (2013.01); A61B 2576/023 (2013.01);
Abstract

Described is a Doppler-based non-invasive computational diagnostic method for personalized cardiology of subjects (e.g., patients with valvular diseases in both pre and post intervention status). The method may be performed for determining dynamic behavior of an aortic valve of the subject, the aortic valve having multiple asymmetric valve leaflets. The method includes receiving Doppler echocardiography images of the subject; processing the received images to reconstruct a 3D geometry of the valve leaflets; determining transient pressure boundary conditions for the valve leaflets using a lumped parameter model specific to the subject; performing a first finite element simulation to determine one or more geometrical parameters for the valve leaflets; iteratively calibrating initial value of one or more material parameters for the subject; and performing a second finite element simulation, based on the calibrated one or more material parameters, to determine an indicator of the dynamic behavior of the aortic valve.


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