The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 01, 2026
Filed:
Mar. 02, 2022
Applicants:
Toppan Holdings Inc., Tokyo, JP;
Osaka University, Suita, JP;
Inventors:
Yasuyuki Hiraoka, Tokyo, JP;
Michiya Matsusaki, Suita, JP;
Assignees:
TOPPAN HOLDINGS INC., Tokyo, JP;
OSAKA UNIVERSITY, Osaka, JP;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 5/071 (2010.01);
U.S. Cl.
CPC ...
C12N 5/0671 (2013.01); C12N 2501/91 (2013.01); C12N 2513/00 (2013.01); C12N 2533/54 (2013.01); C12N 2533/56 (2013.01);
Abstract
Disclosed is a method for producing a cell aggregate having bile canaliculi, including a contact step of bringing cells including hepatocytes into contact with heparin in an aqueous medium and a culture step of culturing the cells brought in contact with the heparin to form the cell aggregate. A concentration of heparin in the aqueous medium when it is brought into contact with the cells may be 0.5 mg/mL or more.