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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12723052 B1

PDFFull Text
Date of Patent:
Sep. 01, 2026

Filed:

Mar. 25, 2022

Tetrahydrothieno pyridine derivatives as ddrs inhibitors

Applicant:

Chiesi Farmaceutici S.p.a., Parma, IT;

Inventors:

Laura Carzaniga, Parma, IT;

Andrea Rizzi, Parma, IT;

Nicolò Iotti, Parma, IT;

Fabio Rancati, Parma, IT;

Anna Karawajczyk, Parma, IT;

Barbara Karolina Wołek, Parma, IT;

David Edward Clark, Parma, IT;

Toby Matthew Grover Mullins, Parma, IT;

Keith Christopher Knight, Parma, IT;

Ben Paul Whittaker, Parma, IT;

Stefano Levanto, Parma, IT;

Assignee:

CHIESI FARMACEUTICI S.P.A., Parma, IT;

Attorney:

Element IP, PLC

Primary Examiner:

Niloofar Rahmani

Int. Cl.
CPC ...
C07D 495/04 (2006.01); A61K 31/437 (2006.01); A61K 31/4436 (2006.01); A61K 31/444 (2006.01); A61K 31/4545 (2006.01); A61K 31/496 (2006.01); A61K 31/4985 (2006.01); A61K 31/501 (2006.01); A61K 31/5025 (2006.01); A61K 31/506 (2006.01); A61K 31/519 (2006.01); A61K 31/5377 (2006.01); A61K 31/5383 (2006.01); C07D 519/00 (2006.01);
U.S. Cl.
CPC ...
C07D 519/00 (2013.01); A61K 31/437 (2013.01); A61K 31/4436 (2013.01); A61K 31/444 (2013.01); A61K 31/4545 (2013.01); A61K 31/496 (2013.01); A61K 31/4985 (2013.01); A61K 31/501 (2013.01); A61K 31/5025 (2013.01); A61K 31/506 (2013.01); A61K 31/519 (2013.01); A61K 31/5377 (2013.01); A61K 31/5383 (2013.01);
Abstract

The present invention relates to compounds of general formula (I) inhibiting Discoidin Domain Receptors (DDR inhibitors), methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful for instance in the treatment of many disorders associated with DDR mechanisms.

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