The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 01, 2026

Filed:

May. 05, 2022
Applicant:

Merck Sharp & Dohme Llc, Rahway, NJ (US);

Inventors:

Ashok Arasappan, Bridgewater, NJ (US);

Ian M. Bell, Lansdale, PA (US);

Jason M. Cox, Rancho Santa Fe, CA (US);

Michael J. Kelly, III, Paoli, PA (US);

Mark Eric Layton, Harleysville, PA (US);

Hong Liu, Hillsborough, NJ (US);

Jian Liu, Norristown, PA (US);

Akshay A Shah, Robbinsville, NJ (US);

Michael D. Vanheyst, Harleysville, PA (US);

Assignee:

Merck Sharp & Dohme LLC, Rahway, NJ (US);

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 401/12 (2006.01); C07D 241/08 (2006.01); C07D 405/12 (2006.01); C07D 417/12 (2006.01);
U.S. Cl.
CPC ...
C07D 401/12 (2013.01); C07D 241/08 (2013.01); C07D 405/12 (2013.01); C07D 417/12 (2013.01); C07B 2200/05 (2013.01);
Abstract

Novel compounds of structural formula (I), and the pharmaceutically acceptable salts thereof, are inhibitors of Na1.8 channel activity and may be useful in the treatment, prevention, management, amelioration, control and suppression of diseases mediated by Na1.8 channel activity. The compounds of Formula I may be useful in the treatment, prevention or management of pain disorders, cough disorders, acute itch disorders, and chronic itch disorders.


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