The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 25, 2026

Filed:

Apr. 13, 2020
Applicant:

Mayo Foundation for Medical Education and Research, Rochester, MN (US);

Inventors:

Anastasia Zekeridou, Rochester, MN (US);

Andrew Mckeon, Rochester, MN (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/564 (2006.01); A61K 31/56 (2006.01); A61P 25/28 (2006.01); C12N 9/16 (2006.01); C12Q 1/44 (2006.01); G01N 33/68 (2006.01);
U.S. Cl.
CPC ...
G01N 33/564 (2013.01); A61K 31/56 (2013.01); A61P 25/28 (2018.01); C12N 9/16 (2013.01); C12Q 1/44 (2013.01); G01N 33/6896 (2013.01); C12Y 301/04017 (2013.01); G01N 2333/916 (2013.01); G01N 2800/24 (2013.01); G01N 2800/2835 (2013.01);
Abstract

Materials and methods are provided herein for detecting the presence of an autoantibody specific for PDE10A to identify the mammal as having an autoimmune neurological disorder as well as methods and materials for treating an autoimmune neurological disorder. Materials and methods also are provided herein for treating cancer and/or neurological autoimmunity in a mammal using an immune checkpoint inhibitor and detecting the presence of an autoantibody specific for PDE10A to monitor for the development of neurologic complications in the mammal.


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