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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12716075 B1

PDFFull Text
Date of Patent:
Aug. 25, 2026

Filed:

Aug. 05, 2020

Compositions for transfecting a nucleic acid molecule into a cell comprising benzo-fused heterocyclic compounds grafted to a cationic polymer, and their applications

Applicant:

Polyplus Transfection, Illkirch-Graffenstaden, FR;

Inventors:

Malik Hellal, Illkirch-Gaffenstaden, FR;

Fabrice Stock, Benfeld, FR;

Patrick Erbacher, Benfeld, FR;

Yann Philipson, Brumath, FR;

Mégane Denu, Illkrich-Graffenstaden, FR;

Marine Ricordel, Dambach la Ville, FR;

Fanny Premartin, Illkirch-Graffenstaden, FR;

Thibaut Benchimol, Erstein, FR;

Mathieu Porte, Lingolsheim, FR;

Valérie Toussaint Moreau, Illkirch-Graffenstaden, FR;

Jonathan Havard, Illkirch-Graffenstaden, FR;

Assignee:

SARTORIUS POLYPLUS, Illkirch-Graffenstaden, FR;

Attorney:

NIXON & VANDERHYE

Primary Examiner:

Jeffrey H Murray

Assistant Examiner:

Kristen W Romero

Int. Cl.
CPC ...
C12N 15/87 (2006.01); A61K 47/59 (2017.01); C08G 73/02 (2006.01); C12N 15/86 (2006.01);
U.S. Cl.
CPC ...
C12N 15/87 (2013.01); A61K 47/59 (2017.08); C08G 73/02 (2013.01); C08G 73/0206 (2013.01); C12N 15/86 (2013.01); C12N 2740/15051 (2013.01); C12N 2740/16043 (2013.01); C12N 2740/16051 (2013.01); C12N 2750/14143 (2013.01); C12N 2750/14151 (2013.01);
Abstract

Compositions for transfecting a nucleic acid molecule into a cell are described. Each composition includes at least one benzimidazole or benzotriazole compound of general formula (II): in which the benzimidazole or benzotriazole ring is substituted at a ring nitrogen by a graft cationic polymer Pthat is a linear or branched polyethyleneimine (PEI) via a —CH—(CH)—CO— linker, where m is 1-3. The remaining ring positions can be unsubstituted or substituted by alkyl, alkoxy, aryl, or related groups. The compositions can further include a nucleic acid molecule together with an acceptable excipient, buffering agent, cell culture medium, or transfection medium, and are useful for in vitro or ex vivo gene delivery with high transfection efficiency and reduced cytotoxicity.

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Hellal, Malik. (2026). Compositions for transfecting a nucleic acid molecule into a cell comprising benzo-fused heterocyclic compounds grafted to a cationic polymer, and their applications (U.S. Patent No. 12716075). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12716075

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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