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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12715880 B1

PDFFull Text
Date of Patent:
Aug. 25, 2026

Filed:

Apr. 07, 2021

Macrocyclic diamine derivatives as ent inhibitors for the treatment of cancers, and combination thereof with adenosine receptor antagonists

Applicant:

Iteos Belgium SA, Gosselies, BE;

Inventors:

Michael Deligny, Rhode-Saint-Genese, BE;

Stefano Crosignani, Vevey, CH;

Erica Joke Katelijne Heleen Houthuys, Enghien, BE;

Michael Rowley, Chelmsford, GB;

Assignee:

ITEOS BELGIUM SA, Gosselies, BE;

Attorney:

McNeill PLLC

Primary Examiner:

Clinton A Brooks

Assistant Examiner:

Kendall Nicole Heitmeier

Int. Cl.
CPC ...
C07D 498/08 (2006.01); A61K 31/395 (2006.01); A61K 31/439 (2006.01); A61K 31/4995 (2006.01); A61K 31/519 (2006.01); A61K 31/551 (2006.01); A61K 45/06 (2006.01); A61P 35/00 (2006.01); C07D 273/08 (2006.01); C07D 487/08 (2006.01); C07D 487/18 (2006.01); C07D 491/08 (2006.01); C07D 498/18 (2006.01);
U.S. Cl.
CPC ...
C07D 498/08 (2013.01); A61K 31/395 (2013.01); A61K 31/551 (2013.01); A61K 45/06 (2013.01); A61P 35/00 (2018.01); C07D 273/08 (2013.01); C07D 487/08 (2013.01); C07D 487/18 (2013.01);
Abstract

The present invention relates to macrocyclic diamine derivatives of formula I, including pharmaceutically acceptable salts and solvates thereof. Compounds of the invention are inhibitors of ENT family transporter, especially of ENT1, and are useful as therapeutic compounds for the treatment of cancers. The invention also relates to the combined use of the macrocyclic diamine derivatives with an adenosine receptor antagonist, for the treatment of cancers.

Find Patent Forward Citations

Deligny, Michael. (2026). Macrocyclic diamine derivatives as ent inhibitors for the treatment of cancers, and combination thereof with adenosine receptor antagonists (U.S. Patent No. 12715880). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12715880

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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