The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 25, 2026

Filed:

Jan. 10, 2020
Applicant:

Uniwersytet Jagiellonski, Cracow, PL;

Inventors:

Stefan Chlopicki, Cracow, PL;

Ivars Kalvins, Riga, LV;

Kamil Przyborowski, Cracow, PL;

Marta Stojak, Cracow, PL;

Victor Andrianov, Riga, LV;

Ilona Domraceva, Riga, LV;

Iveta Kanepe-Lapsa, Riga, LV;

Diana Zelencova, Riga, LV;

Joanna Wietrzyk, Wrocław, PL;

Eliza Turlej, Wrocław, PL;

Martyna Stachowicz, Wrocław, PL;

Joanna Jarosz, Wrocław, PL;

Magdalena Milczarek, Wrocław, PL;

Karol Kramkowski, Białystok, PL;

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 203/24 (2006.01); A61P 7/02 (2006.01); C07D 401/12 (2006.01); C07D 403/12 (2006.01); C07D 413/12 (2006.01);
U.S. Cl.
CPC ...
C07D 401/12 (2013.01); A61P 7/02 (2018.01); C07D 203/24 (2013.01); C07D 403/12 (2013.01); C07D 413/12 (2013.01);
Abstract

The invention relates to a new group of aromatic sulphonamides derivatives of formula (I) and their synthesis and use for modulation of the activity of protein disulfide isomerase (PDI). More particularly, the invention provides small molecule inhibitors of PDI A3 that display antiplatelet, antithrombotic and anticancer activities.


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