logo

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12714716 B1

PDFFull Text
Date of Patent:
Aug. 25, 2026

Filed:

Jun. 27, 2019

Compounds for inhibition of inflammation

Applicant:

Children's Medical Center Corporation, Boston, MA (US);

Inventors:

Hao Wu, Brookline, MA (US);

Judy Lieberman, Brookline, MA (US);

Jun Hu, Boston, MA (US);

Xing Liu, Boston, MA (US);

Assignee:

Children's Medical Center Corporation, Boston, MA (US);

Attorney:

Fish & Richardson P.C.

Primary Examiner:

Lauren Wells

Int. Cl.
CPC ...
A61K 31/555 (2006.01); A61K 31/10 (2006.01); A61K 31/225 (2006.01); A61K 31/385 (2006.01); A61K 31/4025 (2006.01); A61K 31/428 (2006.01); A61K 31/433 (2006.01); A61K 31/444 (2006.01); A61K 31/4545 (2006.01); A61K 31/497 (2006.01); A61K 31/5377 (2006.01); A61K 31/54 (2006.01); A61K 31/553 (2006.01); G01N 33/543 (2006.01);
U.S. Cl.
CPC ...
A61K 31/555 (2013.01); A61K 31/10 (2013.01); A61K 31/225 (2013.01); A61K 31/385 (2013.01); A61K 31/4025 (2013.01); A61K 31/428 (2013.01); A61K 31/433 (2013.01); A61K 31/444 (2013.01); A61K 31/4545 (2013.01); A61K 31/497 (2013.01); A61K 31/5377 (2013.01); A61K 31/54 (2013.01); A61K 31/553 (2013.01); G01N 33/5432 (2013.01); G01N 2500/20 (2013.01);
Abstract

The present application provides chemical compounds useful, for example, in inhibiting gasdermin pore formation in a CA cell, inhibiting inflammasome-mediated death of a cell (pyroptosis); inhibiting cytokine secretion from a cell, inhibiting an inflammatory caspase in a cell, and/or covalently reacting with a cysteine of a gasdermin protein in a cell. These compounds are also useful in treating or preventing diseases or conditions in which inflammasome activation is implicated in pathogenesis. One example of such disease or condition is sepsis.

Find Patent Forward Citations

Wu, Hao. (2026). Compounds for inhibition of inflammation (U.S. Patent No. 12714716). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12714716

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

Loading…