The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 25, 2026
Filed:
Feb. 08, 2019
The United States of America, As Represented BY the Secretary, Department of Health and Human Services, Bethesda, MD (US);
Genome Research Limited, London, GB;
Dana Farber Cancer Institute, Boston, MA (US);
William Curtis Reinhold, Rockville, MD (US);
Mathew Garnett, Cambridge, GB;
Vinodh Nalin Rajapakse, Rockville, MD (US);
Yves Pommier, Bethesda, MD (US);
Augustin Luna, Brookline, MA (US);
The United States of America, as represented by the Secretary, Department of Health and Human Services, Bethesda, MD (US);
Genome Research Limited, London, GB;
Dana Farber Cancer Institute, Boston, MA (US);
Abstract
The disclosure provides a method of treating triple negative breast cancer in a patient, comprising administering a therapeutically effective amount of a compound selected from oxyphenisatin, oxyphenisatin acetate, and bisacodyl, or the pharmaceutically acceptable salts or hydrates of any of the foregoing to the patient. The disclosure also provides methods of using oxyphenisatin or bisacodyl, or a salt or hydrate thereof, as a first active agent in combination with one or more additional active agents to treat triple negative breast cancer. The disclosure further provides methods for determining whether a patient suffering from triple negative breast cancer would be responsive to treatment with oxyphenisatin or bisacodyl.