Closed system for sterile drug preparation and administration

Abstract

A sterile closed system () is provided that includes an airtight enclosure (), an infusion-bag receptacle (), medication-preparation tubing (), one or more medication-preparation-tubing valves (), and an infusion-bag seal (), which is configured to make an airtight seal with respective external surfaces of a medication port () and an IV tubing port () of an infusion bag (). A medication-vial port () is configured to be sealingly coupled to a medication vial (). The sterile closed system () is configured such that a medication-port-interface needle (), disposed within an enclosure interior () of the airtight enclosure (), is sealingly couplable to the medication port () of the infusion bag (), and an IV-tubing-port-interface spike (), disposed within the enclosure interior (), is sealingly couplable to the IV tubing port () of the infusion bag () without breaking the airtight seal between the infusion-bag seal () and the respective external surfaces of the medication port () and the IV tubing port () of the infusion bag (). Other embodiments are also described.