The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 11, 2026
Filed:
Aug. 13, 2021
Arizona Board of Regents on Behalf of Arizona State University, Scottsdale, AZ (US);
Mary Pardhe, Phoenix, AZ (US);
Hugh Mason, Phoenix, AZ (US);
Tsafrir S Leket-Mor, Tempe, AZ (US);
Joshua Pardhe, Phoenix, AZ (US);
ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY, Scottsdale, AZ (US);
Abstract
Provided herein are methods of generating codon optimized nucleotide sequences. The methods include reverse-translating a target amino acid sequence multiple times to generate a plurality of candidate codon optimized nucleotide sequences in which a given codon is randomly selected from synonymous codons encoding a given amino acid residue and incorporated into a given candidate codon optimized nucleotide sequence in the plurality of candidate codon optimized nucleotide sequences. The methods also include determining a total number of occurrences of problematic nucleotide sequences in each of the candidate codon optimized nucleotide sequences to generate a problematic nucleotide sequence count for each of the candidate codon optimized nucleotide sequences. In addition, the methods also include identifying candidate codon optimized nucleotide sequences that comprise a lowest problematic nucleotide sequence count. Additional methods as well as related systems and computer readable media are also provided.