The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 11, 2026
Filed:
Jul. 08, 2020
Applicant:
Icagen, Llc, Emeryville, CA (US);
Inventors:
Paul R. August, Durham, NC (US);
Margaret Kenney, Durham, NC (US);
Jacques Mauger, Durham, NC (US);
Mark Drew, Durham, NC (US);
Weixi Kong, Durham, NC (US);
Assignee:
Icagen, LLC, Emeryville, CA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 409/14 (2006.01); A61P 13/02 (2006.01); C07D 401/04 (2006.01); C07D 405/14 (2006.01); C07D 409/12 (2006.01); C07D 413/14 (2006.01); C07D 471/04 (2006.01); C07D 487/04 (2006.01);
U.S. Cl.
CPC ...
C07D 409/14 (2013.01); A61P 13/02 (2018.01); C07D 401/04 (2013.01); C07D 405/14 (2013.01); C07D 409/12 (2013.01); C07D 413/14 (2013.01); C07D 471/04 (2013.01); C07D 487/04 (2013.01);
Abstract
This disclosure relates to, in part, the treatment of an organic acidemia in a subject in need thereof via administration of a therapeutically effective amount of compounds that inhibit BCAT2. The disclosure also relates to, in part, methods for identifying a candidate compound for treatment of organic acidemias such as maple syrup urinary disease, methylmalonic acidemia, propionic acidemia and isovaleric acidemia.