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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12703695 B1

PDFFull Text
Date of Patent:
Aug. 11, 2026

Filed:

Jul. 29, 2021

Ku inhibitors and their use

Applicant:

Indiana University Research and Technology Corporation, Indianapolis, IN (US);

Inventors:

John J Turchi, Indianapolis, IN (US);

Navnath Gavande, Indianapolis, IN (US);

Pamela S. Vandervere-Carozza, Zionsville, IN (US);

Assignee:

INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION, Indianapolis, IN (US);

Attorney:

Barnes & Thornburg LLP

Primary Examiner:

Anne Marie S Wehbe

Assistant Examiner:

Katie L Pennington

Int. Cl.
CPC ...
C07D 405/14 (2006.01); A61K 31/41 (2006.01); A61K 31/4155 (2006.01); A61P 43/00 (2006.01); C07D 405/06 (2006.01); C07D 409/06 (2006.01); C12N 5/10 (2006.01); C12N 9/22 (2006.01); C12N 9/78 (2006.01); C12N 15/11 (2006.01); C12N 15/87 (2006.01); C12N 15/90 (2006.01);
U.S. Cl.
CPC ...
C07D 405/14 (2013.01); A61K 31/41 (2013.01); A61K 31/4155 (2013.01); A61P 43/00 (2018.01); C07D 405/06 (2013.01); C07D 409/06 (2013.01); C12N 5/10 (2013.01); C12N 9/22 (2013.01); C12N 9/78 (2013.01); C12N 15/111 (2013.01); C12N 15/87 (2013.01); C12N 15/90 (2013.01); C12N 2310/20 (2017.05);
Abstract

The present disclosure relates to certain compounds having binding affinity for Ku, and uses thereof. Specifically, the present disclosure relates to the use of Ku inhibitors as described herein in site-specific genome engineering technologies, including but not limited to CRISPR/Cas9, Zinc finger nuclease (ZFN), Transcription activator-like effector nuclease (TALEN), and meganuclease. The present disclosure also relates to kits useful for site-specific genome engineering that include at least one compound as described herein.

Find Patent Forward Citations

Turchi, John. (2026). Ku inhibitors and their use (U.S. Patent No. 12703695). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12703695

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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