The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 11, 2026

Filed:

Oct. 19, 2021
Applicant:

The Board of Trustees of the Leland Stanford Junior University, Stanford, CA (US);

Inventors:

Utkan Demirci, Stanford, CA (US);

Mehmet Ozgun Ozen, Palo Alto, CA (US);

Naside Gozde Durmus, Stanford, CA (US);

Rakhi Gupta, Cupertino, CA (US);

Sharon Pitteri, Palo Alto, CA (US);

Fernando Jose Garcia Marques, Redwood City, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
B01L 3/00 (2006.01); A61K 35/13 (2015.01); B03C 1/01 (2006.01); B03C 1/28 (2006.01);
U.S. Cl.
CPC ...
B01L 3/502753 (2013.01); A61K 35/13 (2013.01); B01L 3/502761 (2013.01); B03C 1/01 (2013.01); B03C 1/288 (2013.01); B01L 2300/0681 (2013.01); B01L 2300/0819 (2013.01); B01L 2300/0864 (2013.01); B01L 2300/0877 (2013.01); B01L 2300/0896 (2013.01); B01L 2400/043 (2013.01); B01L 2400/0436 (2013.01); B01L 2400/0487 (2013.01); B03C 2201/18 (2013.01); B03C 2201/26 (2013.01);
Abstract

An extracellular vesicle-containing sample can be processed using a device for isolating one or more subpopulations of the extracellular vesicles. The extracellular vesicle-containing sample is flowed through a flow chamber of the device under an applied fluid pressure, in which the device has one or more inlets and two or more outlets in fluid communication with one another via the flow chamber. The device has one or more filters in the flow chamber between the inlet(s) and at least one of the outlet(s). The extracellular vesicle-containing sample is flowed through the filter(s) in the flow chamber to sort the extracellular vesicles of extracellular vesicle-containing sample by size into two or more subpopulations of the extracellular vesicles. At least one of the subpopulations that has been sorted flows out of a corresponding one of the outlets. Surface marker-based exosome sorting using magnetic beads may be used after the size-based exosome isolation.


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