The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 04, 2026

Filed:

Jul. 06, 2023
Applicant:

Pictor Labs, Inc., Los Angeles, CA (US);

Inventors:

Hirofumi Kobayashi, Los Angeles, CA (US);

Yair Rivenson, Los Angeles, CA (US);

Luis Carvalho, Valencia, CA (US);

Assignee:

Pictor Labs, Inc., Los Angeles, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G06V 20/69 (2022.01); G06T 5/20 (2006.01); G06T 5/50 (2006.01); G06T 5/70 (2024.01); G06V 10/30 (2022.01); G06V 10/82 (2022.01);
U.S. Cl.
CPC ...
G06V 20/695 (2022.01); G06T 5/20 (2013.01); G06T 5/50 (2013.01); G06T 5/70 (2024.01); G06V 10/30 (2022.01); G06V 10/82 (2022.01); G06T 2207/20081 (2013.01); G06T 2207/20084 (2013.01); G06T 2207/30024 (2013.01);
Abstract

A method for refining virtually-stained image annotations. The method includes separating an image of a stained tissue section into an image of a counterstain and an image of immunostaining visual signals via linear transformation. The method includes identifying and segmenting nuclei in the image of the counterstain to produce an image of a refined counterstain with single-cell segments. The method includes comparing immunostaining visual signals in the single-cell segments of the image of the refined counterstain to a user-defined threshold to determine true positive cells. The method includes refining the image of the immunostaining visual signals to produce an image of refined immunostaining visual signals. The refining is based on the stained tissue section protein localization or morphology and the determined true positive cells. The method includes overlaying the image of the counterstain and the image of refined immunostaining visual signals to produce a refined virtually-stained image annotation.


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Kobayashi, Hirofumi. (2026). Systems and methods for training machine learning on noisy and inaccurate immunostains (U.S. Patent No. 12700249). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12700249

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