The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 04, 2026

Filed:

Jul. 16, 2020
Applicant:

Ono Pharmaceutical Co., Ltd., Osaka, JP;

Inventors:

Akito Kakuuchi, Osaka, JP;

Shuhei Umemura, Osaka, JP;

Mats Svensson, New York, NY (US);

Anatoly Ruvinsky, Lexington, MA (US);

Daigo Inoyama, Edgewater, NJ (US);

Goran Krilov, Long Island City, NY (US);

Hidenori Takahashi, Lagrangeville, NY (US);

Kyle Konze, Brooklyn, NY (US);

Andreas Verras, New York, NY (US);

Simon Crumpler, Saffron Walden, GB;

Maelle Vallade, Saffron Walden, GB;

Calum Macleod, Saffron Walden, GB;

James N. Sanderson, Saffron Walden, GB;

Richard J. Bull, Saffron Walden, GB;

Simon Gaines, Saffron Walden, GB;

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 487/04 (2006.01); A61K 31/4155 (2006.01); A61K 31/427 (2006.01); A61K 31/4439 (2006.01); A61K 31/519 (2006.01); A61K 31/53 (2006.01); C07D 401/14 (2006.01); C07D 403/12 (2006.01); C07D 471/04 (2006.01); C07D 487/10 (2006.01);
U.S. Cl.
CPC ...
C07D 487/04 (2013.01); A61K 31/4155 (2013.01); A61K 31/427 (2013.01); A61K 31/4439 (2013.01); A61K 31/519 (2013.01); A61K 31/53 (2013.01); C07D 401/14 (2013.01); C07D 403/12 (2013.01); C07D 471/04 (2013.01); C07D 487/10 (2013.01);
Abstract

The compound disclosed is a KDM5 inhibitor represented by the general formula (Z): wherein all symbols have the same meanings as the definitions described in the specification, or a salt thereof, and is useful as a prophylactic and/or therapeutic agent for cancer, Huntington's disease, or Alzheimer's disease and the like.


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