The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 04, 2026
Filed:
Apr. 17, 2020
Applicant:
Translate Bio, Inc., Lexington, MA (US);
Inventors:
Shrirang Karve, Lexington, MA (US);
Saswata Karmakar, Lexington, MA (US);
Frank Derosa, Lexington, MA (US);
Assignee:
TRANSLATE BIO, INC., Waltham, MA (US);
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07C 323/58 (2006.01); A61K 9/1272 (2025.01); A61K 38/17 (2006.01); A61K 38/45 (2006.01);
U.S. Cl.
CPC ...
C07C 323/58 (2013.01); A61K 9/1272 (2013.01); A61K 38/177 (2013.01); A61K 38/45 (2013.01);
Abstract
The present invention provides, in part cystine cationic lipid compounds of formula A, and sub-formulas thereof: or a pharmaceutically acceptable salt thereof. The compounds provided herein can be useful for delivery and expression of mRNA and encoded protein, e.g., as a component of liposomal delivery vehicle, and accordingly can be useful for treating various diseases, disorders and conditions, such as those associated with deficiency of one or more proteins.