The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 04, 2026
Filed:
Aug. 19, 2025
Realeve, Llc, Manalapan, FL (US);
Peter M. Bonutti, Manalapan, FL (US);
Justin E. Beyers, Effingham, IL (US);
Realeve, LLC, Manalapan, FL (US);
Abstract
Systems, devices, and methods for modulating permeability of a membrane barrier (e.g., BBB), such as by increasing and/or decreasing porosity of the membrane barrier. The membrane barrier may be modulated indirectly through neuromodulation, which may include stimulation of an upstream neural body (e.g., a ganglion) that affects, either directly or indirectly, the permeability of the membrane barrier. Modulating a membrane barrier has uses in selective delivery of active agents or other substances through the membrane barrier into tissues or cells. In some situations, these active agents or other substances would not be able to pass through the barrier without modulation. Modulating a membrane barrier has uses in selective drainage of fluid, waste, and/or byproducts from the tissue or cells from one side of the membrane barrier, or reducing the porosity of the membrane barrier to correct a leaky barrier.