The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 04, 2026

Filed:

Jun. 22, 2023
Applicants:

Amylyx Pharmaceuticals, Inc., Cambridge, MA (US);

The Board of Trustees of the Leland Stanford Junior University, Stanford, CA (US);

Inventors:

Xiaofeng Xiong, Santa Clara, CA (US);

Debra Odink, Oakland, CA (US);

Colleen M. Craig, Burlingame, CA (US);

Christine M.N. Smith, San Diego, CA (US);

Tracey L. Mclaughlin, Santa Clara, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/00 (2006.01); A61K 9/00 (2006.01); A61K 38/26 (2006.01); A61K 47/12 (2006.01); A61K 47/26 (2006.01); A61P 3/10 (2006.01);
U.S. Cl.
CPC ...
A61K 47/12 (2013.01); A61K 9/0019 (2013.01); A61K 38/26 (2013.01); A61K 47/26 (2013.01); A61P 3/10 (2018.01);
Abstract

Provided herein are liquid pharmaceutical formulations comprising exendin (9-39) or a pharmaceutically acceptable salt thereof and a tonicity modifier in a physiologically acceptable buffer having a pH in the range of about 5 to about 6. In some embodiments, the buffered liquid formulation comprises exendin (9-39) or a pharmaceutically acceptable salt thereof in an acetate buffer or a citrate buffer. Methods of treating or preventing hyperinsulinemic hypoglycemia in a subject comprising administering to the subject the buffered liquid formulation are also provided.


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