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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12697328 B1

PDFFull Text
Date of Patent:
Aug. 04, 2026

Filed:

Sep. 10, 2021

Methods for treating metastasis with cathepsin c inhibitors

Applicant:

Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai, CN;

Inventors:

Guohong Hu, Shanghai, CN;

Yansen Xiao, Shanghai, CN;

Min Cong, Shanghai, CN;

Chenxi Liang, Shanghai, CN;

Assignee:

SHANGHAI INSTITUTE OF NUTRITION AND HEALTH, CHINESE ACADEMY OF SCIENCES, Shanghai, CN;

Attorneys:

NKL Law

Bin Lu

Allen Xue

Primary Examiner:

Jeffrey S Lundgren

Assistant Examiner:

Anthony Joseph Seitz

Int. Cl.
CPC ...
A61K 31/439 (2006.01); A61K 31/277 (2006.01); A61K 31/4045 (2006.01); A61K 31/495 (2006.01); A61K 31/496 (2006.01); A61K 38/05 (2006.01); A61P 35/00 (2006.01);
U.S. Cl.
CPC ...
A61K 31/439 (2013.01); A61K 31/277 (2013.01); A61K 31/4045 (2013.01); A61K 31/495 (2013.01); A61K 31/496 (2013.01); A61K 38/05 (2013.01); A61P 35/00 (2018.01);
Abstract

Provided herein are methods for treating metastasis of a cancer with a pharmaceutical composition comprising an effective amount of a cathepsin C (CTSC) inhibitor. The CTSC inhibitor, in some embodiments, is a compound of Formula (I), or a pharmaceutically acceptable salt thereof, for example, brensocatib. The treatment methods inhibit, slow, or reverse the progression of the metastasis. In some embodiments, the methods further comprise reducing neutrophil infiltration and/or formation of neutrophil extracellular traps (NETs).

Find Patent Forward Citations

Hu, Guohong. (2026). Methods for treating metastasis with cathepsin c inhibitors (U.S. Patent No. 12697328). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12697328

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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