The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 28, 2026

Filed:

Sep. 25, 2019
Applicant:

Abbott Diabetes Care Inc., Alameda, CA (US);

Inventors:

Tianmei Ouyang, Fremont, CA (US);

Benjamin J. Feldman, Berkeley, CA (US);

Hyun Cho, Berkeley, CA (US);

Assignee:

Abbott Diabetes Care Inc., Alameda, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/70 (2006.01); A61B 5/145 (2006.01); A61B 5/1473 (2006.01); A61B 5/1486 (2006.01); C12Q 1/00 (2006.01); G01N 27/327 (2006.01);
U.S. Cl.
CPC ...
G01N 27/3271 (2013.01); A61B 5/1451 (2013.01); A61B 5/14532 (2013.01); A61B 5/14546 (2013.01); A61B 5/14735 (2013.01); A61B 5/1486 (2013.01); A61B 5/14865 (2013.01); C12Q 1/002 (2013.01); C12Q 1/005 (2013.01); C12Q 1/006 (2013.01); G01N 27/327 (2013.01); A61B 2562/02 (2013.01); C12Y 101/03004 (2013.01); C12Y 105/03001 (2013.01); C12Y 305/0201 (2013.01); C12Y 305/03003 (2013.01); G01N 2333/904 (2013.01); G01N 2333/90683 (2013.01); G01N 2333/978 (2013.01); G01N 2333/986 (2013.01);
Abstract

Creatinine levels may be monitored as a measure of kidney function. Conventionally, blood and/or urine tests are used for this purpose. Analyte sensors capable of monitoring creatinine in vivo may comprise: a sensor tail comprising at least a first working electrode, a creatinine-responsive active area disposed upon a surface of the first working electrode, a first membrane that is permeable to creatinine and overcoats the creatinine-responsive active area, and an oxygen scavenger located upon the sensor tail in proximity to the creatinine-responsive active area. The creatinine-responsive active area comprises a first electron transfer agent, a first polymer, and an enzyme system comprising multiple enzymes, particularly creatinine amidohydrolase, creatine amidinohydrolase, and sarcosine oxidase, that are capable of acting in concert to facilitate detection of creatinine. An oxidase enzyme may serve as the oxygen scavenger, particularly glucose oxidase when detecting creatinine in fluids also containing glucose.


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