The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 28, 2026
Filed:
Mar. 25, 2022
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, CN;
Suzhou Qingya Qirui Biotechnology Co., Ltd., Jiangsu, CN;
Jianhua Shen, Shanghai, CN;
Zhiyuan Zhu, Jiangsu, CN;
Xiaomei Li, Shanghai, CN;
Kai Wang, Shanghai, CN;
Jia Liu, Shanghai, CN;
SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCE, Shanghai, CN;
SUZHOU QINGYA QIRUI BIOTECHNOLOGY CO., LTD., Jiangsu, CN;
Abstract
Disclosed in the present invention are a lignan derivative, a preparation method therefor and the use thereof. The structure of the lignan derivative is as shown in a formula I, wherein in the formula, the definition of each substituent is as described in the description and claims. The lignan derivative of the present invention can be used as an inhibitor of mitochondrial respiratory chain complex I to inhibit mitochondrial oxidative phosphorylation and ATP generation, and can also be used for preventing and/or treating diseases associated with the elevated activity or expression of the mitochondrial respiratory chain complex I or enhanced mitochondrial oxidative phosphorylation.