The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 28, 2026
Filed:
Feb. 01, 2022
Applicant:
Inventure, Llc, Southbury, CT (US);
Inventors:
Richard J. Deslauriers, Woodbury, CT (US);
Michael Milbocker, Holliston, MA (US);
Paul Lombardo, Stamford, CT (US);
Assignee:
INVENTURE, LLC, Southbury, CT (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07F 5/00 (2006.01); A61K 51/04 (2006.01);
U.S. Cl.
CPC ...
C07F 5/003 (2013.01); A61K 51/0482 (2013.01);
Abstract
Macrocyclic gadolinium-based contrast agents (GCA) are synthesized by pathways characterized by the formation of a sequence of metastable complexes before obtaining the final stable complex. Commercial macrocyclic GCAs contain unstable metastable complexes. These metastable species quickly release free Gd3+ ions upon delivery into the body. Aqueous or dry/solid GCA with near zero metastable species content and methods of synthesizing the same are disclosed.