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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12692252 B1

PDFFull Text
Date of Patent:
Jul. 28, 2026

Filed:

May. 12, 2022

Compound having anti-tumor activity and use thereof

Applicant:

Innovstone Therapeutics Limited, Shanghai, CN;

Inventors:

Yunlong Song, Shanghai, CN;

Wenqing Xu, Shanghai, CN;

Hongyan Kou, Shanghai, CN;

Yongzhao Mu, Shanghai, CN;

Qun Dang, Shanghai, CN;

Pan Li, Shanghai, CN;

Zhou Yin, Shanghai, CN;

Jianbin MA, Shanghai, CN;

Xiaodan Fu, Shanghai, CN;

Xin Cai, Shanghai, CN;

Yan Li, Shanghai, CN;

Assignee:

Innovstone Therapeutics Limited, Shanghai, CN;

Attorney:

Buchanan Ingersoll & Rooney PC

Primary Examiner:

Jeffrey S Lundgren

Assistant Examiner:

Ibrahim D Bori

Int. Cl.
CPC ...
C07D 401/14 (2006.01); A61K 31/4725 (2006.01); A61K 31/506 (2006.01); A61K 31/519 (2006.01); A61K 31/52 (2006.01); A61K 31/53 (2006.01); A61K 31/5377 (2006.01); A61P 35/00 (2006.01); C07D 401/04 (2006.01); C07D 405/14 (2006.01); C07D 409/14 (2006.01); C07D 413/14 (2006.01); C07D 417/14 (2006.01); C07D 471/04 (2006.01); C07D 471/08 (2006.01); C07D 473/00 (2006.01); C07D 513/04 (2006.01);
U.S. Cl.
CPC ...
C07D 401/14 (2013.01); A61K 31/4725 (2013.01); A61K 31/506 (2013.01); A61K 31/519 (2013.01); A61K 31/52 (2013.01); A61K 31/53 (2013.01); A61K 31/5377 (2013.01); A61P 35/00 (2018.01); C07D 401/04 (2013.01); C07D 405/14 (2013.01); C07D 409/14 (2013.01); C07D 413/14 (2013.01); C07D 417/14 (2013.01); C07D 471/04 (2013.01); C07D 471/08 (2013.01); C07D 473/00 (2013.01); C07D 513/04 (2013.01);
Abstract

Provided is a compound having anti-tumor activity and a use thereof. As a PRMT5 inhibitor, the compound has a structure represented by formula (I). Experiments have confirmed that these compounds have strong inhibitory effects on PRMT5 enzyme activity and tumor cell growth, and can be used as promising compounds for treating PRMT5-mediated diseases. Furthermore, a specific synthesis method is further studied. The synthesis method is simple in process, convenient to operate, and beneficial to large-scale industrial production and application.

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