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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12692236 B1

PDFFull Text
Date of Patent:
Jul. 28, 2026

Filed:

Nov. 26, 2019

Small molecule modulators of sigma-1 and sigma-2 receptors and uses thereof

Applicant:

Northwestern University, Evanston, IL (US);

Inventors:

Gary E. Schiltz, Naperville, IL (US);

Iredia D. Iyamu, Evanston, IL (US);

Rama K. Mishra, Chicago, IL (US);

Wei Lv, Evanston, IL (US);

Neha Malik, Evanston, IL (US);

Assignee:

Northwestern University, Evanston, IL (US);

Attorneys:

Casimir Jones, S.C.

Robert A. Goetz

Primary Examiner:

Jeanette M Lieb

Int. Cl.
CPC ...
C07D 231/00 (2006.01); A61K 31/416 (2006.01); A61K 31/4178 (2006.01); A61K 31/422 (2006.01); A61K 31/437 (2006.01); A61K 31/4439 (2006.01); A61K 31/454 (2006.01); A61K 31/4545 (2006.01); A61K 31/4725 (2006.01); A61K 31/496 (2006.01); A61K 31/4985 (2006.01); A61K 31/506 (2006.01); A61K 31/5377 (2006.01); A61K 31/551 (2006.01); A61K 47/55 (2017.01); A61K 47/64 (2017.01); C07D 231/56 (2006.01); C07D 401/12 (2006.01); C07D 401/14 (2006.01); C07D 403/12 (2006.01); C07D 405/12 (2006.01); C07D 413/12 (2006.01); C07D 471/04 (2006.01); C07D 487/04 (2006.01);
U.S. Cl.
CPC ...
C07D 231/56 (2013.01); A61K 31/416 (2013.01); A61K 31/4178 (2013.01); A61K 31/422 (2013.01); A61K 31/437 (2013.01); A61K 31/4439 (2013.01); A61K 31/454 (2013.01); A61K 31/4545 (2013.01); A61K 31/4725 (2013.01); A61K 31/496 (2013.01); A61K 31/4985 (2013.01); A61K 31/506 (2013.01); A61K 31/5377 (2013.01); A61K 31/551 (2013.01); A61K 47/55 (2017.08); A61K 47/64 (2017.08); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 403/12 (2013.01); C07D 405/12 (2013.01); C07D 413/12 (2013.01); C07D 471/04 (2013.01); C07D 487/04 (2013.01);
Abstract

This invention is in the field of medicinal chemistry. In particular, the invention relates to anew class of small-molecules having a tetrahydroindazole structure which function as modulators (e.g., activators or inhibitors) of sigma-1 and/or sigma-2 receptors, and their use as therapeutics for the treatment of cancer and other diseases (e.g., neurological conditions) characterized with sigma-1 and/or sigma-2 receptor activity.

Find Patent Forward Citations

Schiltz, Gary. (2026). Small molecule modulators of sigma-1 and sigma-2 receptors and uses thereof (U.S. Patent No. 12692236). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12692236

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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