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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12691161 B1

PDFFull Text
Date of Patent:
Jul. 28, 2026

Filed:

Apr. 27, 2021

Mechanical and biochemical activation and control of skeletal stem cells for cartilage regeneration

Applicant:

The Board of Trustees of the Leland Stanford Junior University, Stanford, CA (US);

Inventors:

Michael T. Longaker, Atherton, CA (US);

Charles K.F Chan, Redwood City, CA (US);

Matthew Philip Murphy, Palo Alto, CA (US);

Assignee:

The Board of Trustees of the Leland Stanford Junior University, Stanford, CA (US);

Attorneys:

Pamela J. Shewood

Bozicevic, Field & Francis LLP

Primary Examiner:

Xiaozhen Xie

Int. Cl.
CPC ...
A61K 38/18 (2006.01); A61K 35/545 (2015.01); A61K 38/17 (2006.01); A61K 45/06 (2006.01); A61L 27/58 (2006.01); A61P 19/02 (2006.01); C07K 16/28 (2006.01);
U.S. Cl.
CPC ...
A61K 38/1875 (2013.01); A61K 35/545 (2013.01); A61K 38/17 (2013.01); A61K 45/06 (2013.01); A61L 27/58 (2013.01); A61P 19/02 (2018.01); C07K 16/2863 (2013.01); A61L 2300/412 (2013.01); A61L 2430/06 (2013.01);
Abstract

Methods and compositions are provided for the regeneration of articular cartilage by activating skeletal stem cells with a combination of (i) mechanical and (ii) biochemical stimulus. The mechanical stimulus can be an acute local injury. The biochemical stimulus can be a combination of an effective dose of a BMP2 activating agent and a VEGF inhibitor.

Find Patent Forward Citations

Longaker, Michael. (2026). Mechanical and biochemical activation and control of skeletal stem cells for cartilage regeneration (U.S. Patent No. 12691161). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12691161

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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