The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 28, 2026
Filed:
Jul. 11, 2019
The Hong Kong University of Science and Technology, Hong Kong, CN;
THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY, Hong Kong, CN;
Abstract
Antibiotic compounds having both antibiotic and aggregation-induced emission (AIE) characteristics. The compounds comprise an azole antibiotic unit, for example naphthalimide triazole (NT), and an AIE unit, for example triphenylethylene (TriPE). The compounds act as an effective AIEgen with ROS generating capabilities. The present combinations of an azole antibiotic unit and an AIE unit do not negatively affect the antibacterial properties of the azole. Accordingly, the present compounds exterminate bacteria with both the antibacterial mechanism of the azole along with the ROS produced when the AIE unit is exposed to light. In addition, the intrinsic imagining ability of the present compounds enables them to be used as imaging tools to monitor the drug-bacteria interaction. Collectively, the present compounds provide multiple functions including imaging, monitoring, and bacterial infection inhibition for integrated diagnosis and treatment in clinical practices.