The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 21, 2026
Filed:
Apr. 07, 2020
Applicant:
Aspect Biosystems Ltd., Vancouver, CA;
Inventors:
Dorthe Roenn Petersen, Slangerup, DK;
Christian Honore, Vanloese, DK;
Assignee:
ASPECT BIOSYSTEMS LTD., Vancouver, CA;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 5/071 (2010.01); A61K 35/39 (2015.01);
U.S. Cl.
CPC ...
C12N 5/0676 (2013.01); A61K 35/39 (2013.01); C12N 2501/10 (2013.01); C12N 2501/115 (2013.01); C12N 2501/155 (2013.01); C12N 2501/385 (2013.01); C12N 2501/727 (2013.01); C12N 2506/45 (2013.01);
Abstract
The present invention relates to methods of efficiently generating pancreatic endoderm from human pluripotent stem (PS) cell derived human definitive endoderm. The present invention also relates to pancreatic endoderm cells obtained by the methods of the invention. Finally, the present invention relates to culture medium and composition comprising a RAR antagonist and uses of said RAR antagonist in the induction of pancreatic endoderm cells. The present invention provides a more homogenous and synchronised pancreatic cell population, with increased efficiency.